Survivin-positive circulating tumor cells as a marker for metastasis of hepatocellular carcinoma

Figure 2 Analysis of survivin gene expression in normal liver tissue and hepatocellular cancer tissue from previously reported genome data. A: The expression patterns in 21 normal tissue samples and 22 hepatocellular carcinoma samples were analyzed by hierarchical clustering; B: Ingenuity pathway analysis was used to identify the upregulated pathways (Z-score > 0) and the downregulated pathways (Z-score < 0) in the normal tissue samples and hepatocellular cancer (HCC) samples; C: The FPKM (fragments per kilobase of transcript per million fragments mapped) of survivin was determined for different samples. Compared with normal liver tissue samples, the expression of the survivin gene was upregulated in HCC samples.