Impact of preoperative antibiotics and other variables on integrated microbiome-host transcriptomic data generated from colorectal cancer resections

Table 6 The operational taxonomic units (genus level) without significant tumor histology*preoperative antibiotics interaction terms, with significant (P < 0.05 after Bonferroni correction) estimated tumor/nontumor ratios of relative abundance and 95% confidence intervals

OTU	Ratio (95%CI)	P value
Increased in tumor
Firmicutes/Carnobacteriaceae/unspecified	22.21 (7.57, 65.21)	< 0.0001
Firmicutes/ Peptoniphilus	2.13 (1.45, 3.13)	0.0042
Firmicutes/Catenibacterium	3.89 (1.79, 8.46)	0.0206
Firmicutes/Dialister	2.05 (1.48, 2.83)	0.0005
Fusobacteria/Fusobacterium	5.30 (2.82, 9.97)	< 0.0001
Proteobacteria/Campylobacter	7.40 (3.30, 16.62)	< 0.0001
Proteobacteria/Citrobacter	3.51 (2.12, 5.81)	< 0.0001
Decreased in tumor
Actinobacteria/Coriobacteriaceae/unspecified	0.45 (0.32, 0.64)	0.0003
Bacteroidetes/unspecified	0.49 (0.32, 0.74)	0.0240
Bacteroidetes/S24-7	0.50 (0.36, 0.70)	0.0016
Cyanobacteria/Chloroplast	0.44 (0.31, 0.64)	0.0021
Firmicutes/Lachnospiraceae/unspecified	0.76 (0.68, 0.84)	< 0.0001
Firmicutes/Marvinbryantia	0.39 (0.24, 0.65)	0.0113
Firmicutes/vadinBB60	0.50 (0.36, 0.70)	0.0052
Firmicutes/Turicibacter	0.44 (0.30, 0.66)	0.0074
Firmicutes/Allobaculum	0.43 (0.29, 0.62)	0.0002
Proteobacteria/Rickettsiales/mitochondria	0.32 (0.19, 0.53)	0.0003
Tenericutes/Anaeroplasma	0.42 (0.28, 0.62)	0.0004
Verrucomicrobia/Akkermansia	0.58 (0.42, 0.80)	0.0350

OTU: Operational taxonomic unit; CI: Confidence interval.