Factors influencing the short-term and long-term survival of hepatocellular carcinoma patients with portal vein tumor thrombosis who underwent chemoembolization

Table 4 Univariate analysis of survivors vs non-survivors at 12 mo after transarterial chemoembolization

Parameters	Survivors, n = 31	Non-survivors, n = 150	P value
Age in yr	54.770 ± 10.724	51.800 ± 9.400	0.225
Sex, men/women	28/3	131/19	0.871
Cause of liver disease, hepatitis B/C/B and C/others	30/0/0/1	133/3/1/13	0.751
Tumor size, < 5 cm/≥ 5 cm, < 10 cm/≥ 10 cm	11/14/6	28/72/50	0.081
Number of tumors, 1/2/≥ 3	21/4/6	61/8/81	0.002
Liver cirrhosis, no/yes	4/27	44/106	0.059
Ascites, no/small/moderate-massive	16/11/4	75/59/16	0.892
CTPV, no/yes	26/5	132/18	0.74
Invade left and right liver lobes, no/yes	26/5	93/57	0.019
Type of gross pathology, massive/nodular and diffuse	13/18	99/51	0.012
PVTT type, I/II, III/IV	7/10/11/3	22/67/57/4	0.155
Inferior vena cava tumor thrombus, no/yes	30/1	141/9	0.854
Arteriovenous fistula, no/yes	21/10	104/46	0.861
Total bilirubin, µmol/L	19.550 (11.200-33.400)	16.600 (12.900-24.000)	0.436
Prealbumin, mg/L	124.500 (86.750-160.500)	105.000 (78.000-142.000)	0.163
Albumin, g/L	37.047 ± 5.635	36.813 ± 4.622	0.669
Hemoglobin, g/L	132.500 (117.500-146.500)	125.000 (115.000-142.000)	0.316
WBC, 109/L	4.565 (3.398-5.850)	5.100 (4.050-6.610)	0.284
PLT, 109/L	89.000 (63.250-126.000)	119.000 (87.000-182.000)	0.046
INR	1.120 (1.070-1.253)	1.110 (1.050-1.200)	0.281
PT, S	14.400 (13.850-15.875)	14.300 (13.700-15.200)	0.266
APTT, S	39.200 (36.450-42.075)	39.700 (37.100-42.900)	0.541
ALT, U/L	46.500 (38.500-72.000)	45.000 (30.000-72.000)	0.770
AST, U/L	56.500 (41.750-83.750)	71.000 (46.000-115.000)	0.108
GGT, U/L	177.500 (72.250-265.250)	216.000 (132.000-356.000)	0.036
Cholinesterase, kU/L	4.25 (2.775-5.905)	4.51 (3.08-5.79)	0.945
Creatinine, µmol/L	71.300 (61.475-79.500)	67.600 (57.400-78.100)	0.220
AFP, µg/L	568 (15.13~1210)	1210 (97.335-1210)	0.188
Child-Pugh grade, A/B/C	19/11/1	104/44/2	0.373
ECOG score, 0/1/2/3	4/24/3/0	4/118/26/2	0.086
ALBI grade, 1/2/3	13/16/2	43/104/3	0.09
MELD score	7.130 (5.548-9.315)	7.860 (6.070-9.790)	0.348

AFP: Alpha fetoprotein; ALBI: Albumin-bilirubin; ALT: Alanine aminotransferase; APTT: Activated partial thromboplastin time; AST: Aspartate aminotransferase; CTPV: Cavernous transformation of the portal vein; ECOG: Eastern Cooperative Oncology Group; GGT: Gamma-glutamyl transpeptidase; INR: International normalized ratio; MELD: Model of end-stage liver disease; PLT: Platelets; PVTT Portal vein tumor thrombosis; WBC: White blood cell.