Copyright ©The Author(s) 2020.
World J Gastroenterol. Jun 21, 2020; 26(23): 3170-3181
Published online Jun 21, 2020. doi: 10.3748/wjg.v26.i23.3170
Table 3 Chemopreventive activities of urolithin A against other cancers of the alimentary tract
Cell line/modelMechanismRef.
HepG2↓Cell survivalWang et al[50]
↓Wnt/β-catenin signalling; β-catenin
c-MYc, cyclin D1, phospo-c-Jun
IL-6, IL-1β, NF-κβ, Cox-2, iNOS
TP53, BAX, PUMA, NOXA, p53, phosphor-p53
Caspase-3, phospho-p38
↓H2O2-induced ROS, MDA level
↑SOD level, GPx activity in H2O2-induced oxidative stress
HepG2.2.15↓Cell proliferationQiu et al[51]
↑Cleaved caspase-3, Bax
↓Lin28a, Zcchc11, Sp-1
↓HMGA2, K-ras
↓Invasive cell number
Cultured rat hepatocytes/t-BHT↓CytotoxicityOlennikov et al[55]
↓LDH, MDA level
The human PDAC cell lines (MiaPaCa2, PANC1, AsPC1, CFPAC1, Capan1, Capan2, SW1990, HPAC, BxPC3)↓Cell proliferation, migration, apoptosisTotiger et al[58]
↓pAKT (T308), p70S6K (T421/S424), PDK1, pGSK3β, p4E-BP1
PDAC xenografts in mice↓Tumor volumeTotiger et al[58]
↓pAKT (T308), p70S6K (T421/S424)
↑Cleaved caspase-3
PKT mice↓Tumor weightTotiger et al[58]
↓pAKT (T308), p70S6K (T421/S424)
↑Cleaved caspase-3
↓F4/80-, Fox-P3, CD3- positive cells
BE patients/LBR intervention↑GST-pi level in BE biopsiesKresty et al[59]