Observational Study
Copyright ©The Author(s) 2020.
World J Gastroenterol. Jun 14, 2020; 26(22): 3098-3109
Published online Jun 14, 2020. doi: 10.3748/wjg.v26.i22.3098
Table 2 Variants/mutations in Crohn's disease candidate genes and the alteration of intestinal microbiome
Ref.GeneHuman/animalMajor findings
[6,19]IL10Il10-/- miceDecrease in diversity and richness
Proteobacteria and Escherichia coli (during onset of inflammation)
Bacteroidetes and Firmicutes
Current studyIL10RAHuman cohortDecrease in diversity and increase in variability
Firmicutes, Enterococcaceae, Enterococcus, Lactobacillales, Bacilli, and Micrococcales
Bifidobacteriales, Bifidobacteriaceae, Bifidobacterium, Veillonellaceae, Clostridiales, Clostridia, Selenomonadales, and Negativicutes
[4,7,20]NOD2Human cohortRoseburia, Faecalibacterium prausnitzii, Bacteroides and Bacteroidia
Eubacteriaceae and Enterobacteriaceae
[21]NOD2Nod2-/- miceDecrease in diversity and richness
Bacteroides, Bacteroidaceae, and B.acidifaciens
Proteobacteria, Helicobacter hepaticus, and Desulfovibro spp
[22]ATG16L1Human cohortFusobacteriaceae
[4]CARD9Human cohortFirmicutes
[23]CARD9Card9-/- miceDecreased stability
Adlercreutzia, Actinobacteria, and Lactobacillus reuteri