Single-nucleotide polymorphisms based genetic risk score in the prediction of pancreatic cancer risk

doi:10.3748/wjg.v26.i22.3076

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2020; 26(22): 3076-3086
Published online Jun 14, 2020. doi: 10.3748/wjg.v26.i22.3076

Table 3 Univariate/multivariate logistic regression results

Univariate logistic regression		OR (95%CI)	P value
	GRS	1.23 (1.13-1.34)	< 0.0001
Multivariate logistic regression		OR (95%CI)	P value
	GRS	1.36 (1.06-1.74)	0.015
	Age at diagnosis/enrollment	1.14 (1.12-1.17)	< 0.0001
	Sex	0.84 (0.61-1.16)	0.28
Subgroup analysis¹		OR (95%CI)	P value
	GRS: < 1 (Ref)²	-	-
	GRS: 1-2	1.39 (1.03-1.84)	0.031
	GRS: > 2	1.99 (1.30-3.04)	0.002
	< 10^th P (Ref)³	-	-
	10^th-50^th P	1.18 (0.69-2.01)	0.548
	50^th-90^th P	1.57 (0.93-2.66)	0.089
	> 90^th P	2.29 (1.25-4.21)	0.007

¹Univariate mode.

²P trend = 0.0006.

³P trend = 0.0008. OR: Odds ratio; CI: Confidence interval; GRS: Genetic risk score.

Citation: Wang XY, Chen HT, Na R, Jiang DK, Lin XL, Yang F, Jin C, Fu DL, Xu JF. Single-nucleotide polymorphisms based genetic risk score in the prediction of pancreatic cancer risk. World J Gastroenterol 2020; 26(22): 3076-3086
URL: https://www.wjgnet.com/1007-9327/full/v26/i22/3076.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i22.3076