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©The Author(s) 2020.
World J Gastroenterol. May 21, 2020; 26(19): 2305-2322
Published online May 21, 2020. doi: 10.3748/wjg.v26.i19.2305
Published online May 21, 2020. doi: 10.3748/wjg.v26.i19.2305
Table 4 Several editions of World Health Organization (pathological classification)
| Edition | Grading standards | |||
| 2000/2004 | G1: Well-differentiated NET; ≤ 2 cm in size, Ki-67 ≤ 2% | G2: Well-differentiated NEC; > 2 cm in size, Ki-67 3%-20% or angioinvasive | G3: Poorly differentiated NEC; Ki-67 > 20% | |
| 2010 | NET-G1: Well-differentiated, mitotic count < 2/2 mm2, Ki-67 ≤ 2% | NET-G2: Well-differentiated, mitotic count 2-20/2 mm2, Ki-67 3%-20% | NEC-G3: Poorly differentiated, mitotic count > 20/2 mm2, Ki-67 > 20% | |
| 2017/2019 | NET-G1: Well-differentiated, mitotic count < 2/2 mm2, Ki-67 ≤ 2% | NET-G2: Well-differentiated, mitotic count 2-20/2 mm2, Ki-67 3%-20% | NET-G3: Well-differentiated, mitotic count > 20/2 mm2, Ki-67 > 20% | NEC-G3: Poorly differentiated, mitotic count > 20/2 mm2, Ki-67 > 20% |
- Citation: Ma ZY, Gong YF, Zhuang HK, Zhou ZX, Huang SZ, Zou YP, Huang BW, Sun ZH, Zhang CZ, Tang YQ, Hou BH. Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management. World J Gastroenterol 2020; 26(19): 2305-2322
- URL: https://www.wjgnet.com/1007-9327/full/v26/i19/2305.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i19.2305