Targeted and immune therapies for hepatocellular carcinoma: Predictions for 2019 and beyond

Table 6 Results of the REACH-2 trial[49]

	Ramucirumab (n = 197)	Placebo (n = 95)	HR, P-value
OS (M, 95%CI)	8.5	7.3	HR 0.710 (95%CI 0.531-0.949) P = 0.0199
PFS (M, 95%CI)	2.8	1.6	HR 0.452 (95%CI 0.339-0.603) P < 0.0001
Objective response (RECIST 1.1)
CR (n, %)	0 (0.0)	0 (0.0)
PR (n, %)	9 (4.6)	1 (1.1)
SD (n, %)	109 (55.3)	36 (37.9)
PD (n,%)	66 (33.5)	48 (50.5)
NE (n, %)	13 (6.6)	10 (10.5)
ORR (%, 95CI)	9 (4.6)	1 (1.1)	P = 0.1697
DCR (%)	118 (59.9)	37 (38.9)	P = 0.0006

OS: Overall survival; PFS: Progression-free survival; TTP: Time to progression; CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease; NE: Not evaluable; ORR: Objective response rate; DCR: Disease control rate.