Berberine prevents stress-induced gut inflammation and visceral hypersensitivity and reduces intestinal motility in rats

Figure 8 Effects of berberine on brain derived neurotrophic factor and Trkb mRNA and protein expression. Expression of brain derived neurotrophic factor and Trkb mRNA and protein in 1: control group; 2: water avoidance stress (WAS) group; 3: rifaximin group; 4: 25 mg/kg berberine (BBR) group; and 5: 100 mg/kg BBR group. Letters a, b, and c: P < 0.05 compared with those in the control group, WAS group, and 25 mg/kg BBR group, respectively. BDNF: Brain derived neurotrophic factor; WAS: Water avoidance stress; BBR: Berberine.