Copyright ©The Author(s) 2017.
World J Gastroenterol. Sep 7, 2017; 23(33): 6016-6029
Published online Sep 7, 2017. doi: 10.3748/wjg.v23.i33.6016
Table 2 Role of the different classes of mucins in dextran sodium sulfate induced colitis
Mucin geneMucin classExpression site (GI tract)ChromosomePathological findings with DSS treatmentRef.
Muc1Membrane boundAll epithelia3Muc1-/- protective when challenged with DSS[64,66]
Increased thickness with adherent mucus
Muc3Membrane boundIntestine, enterocytes5Increased up-regulation of Muc3 gene[65,66]
Muc4Membrane boundAll epithelian.d.Large type I transmembrane glycoprotein[65,66,73]
Muc4-/- more resistant to colitis due to up-regulation of Muc2 due to increase proliferation of cytokines
Muc2SecretoryIntestine, goblet cells7Muc2-/- more susceptible to spontaneous colitis, increased risk of CAC[66-68]
DSS produces fulminant colitis vs wild type
Muc5bSecretoryTongue, sublingual glands7[66]