Copyright ©The Author(s) 2017.
World J Gastroenterol. Aug 7, 2017; 23(29): 5266-5281
Published online Aug 7, 2017. doi: 10.3748/wjg.v23.i29.5266
Figure 2
Figure 2 Proposed models of Galectin-1 contribution to the progression of gastric cancer, hepatocellular carcinoma, colorectal cancer and pancreatic ductal adenocarcinoma. Galectin-1 (Gal-1) has key functions in tumor and tumor-associated stromal cells, favoring tumor cell proliferation and dissemination, angiogenesis and immunosuppression. A high exposure of Gal-1 glycan partners also contribute to tumor progression. ECM: Extracellular matrix; EMT: Epithelial-mesenchymal transition; GnTV: β1,6-N-acetylglucosaminyltransferase V; HSC: Hepatic stellate cell; PSC: Pancreatic stellate cell; TGF-β1: Transforming growth factor beta 1.