Aberrant regulation of Wnt signaling in hepatocellular carcinoma

Figure 3 Regulation of wingless/int-1 signaling by crosstalk in hepatocellular carcinoma. The crosstalk between other signaling cascades and the Wnt signaling pathways involved in hepatocarcinogenesis are shown (see text). Lines ending with arrows or bars indicate activating or inhibitory effects respectively. The distinct line colors indicate the different pathways that crosstalk with Wnt signaling, including: Wnt signaling pathway (black), TGF-β pathway (green), HGF/c-Met pathway (blue), HIF-1α/EMT pathway (yellow), and IGF-1 pathway (purple). Wnt: Wingless/int-1; TGF-β: Transforming growth factor beta; HGF: Hepatocyte growth factor; HIF-1α: Hypoxia- inducible factor-1 alpha; EMT: Epithelial-mesenchymal transition; IGF-1: Insulin/insulin-like growth factor-1.