Copyright ©The Author(s) 2016.
World J Gastroenterol. Apr 7, 2016; 22(13): 3516-3530
Published online Apr 7, 2016. doi: 10.3748/wjg.v22.i13.3516
Figure 4
Figure 4 MAPK pathway. This simplified diagram of the MAPK pathway shows the RAS/Raf-1/MEK/ERK pathway. RAS mutations are found in 36% of serrated polyps, and Raf-1 mutations are found in 9%-11%. These mutations promote gene transcription and cellular growth that results in cellular adhesion, invasion, metastasis, and angiogenesis.