Overview of hepatitis B virus mutations and their implications in the management of infection

doi:10.3748/wjg.v22.i1.145

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 7, 2016; 22(1): 145-154
Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.145

Table 1 Cross-resistance data for the most frequent resistant hepatitis B virus variant

HBV variants	Level of susceptibility
HBV variants	Lamivudine	Telbivudine	Entecavir	Adefovir	Tenofovir
Wild-tipe	S	S	S	S	S
M204V	R	S	I	I	S
M204I	R	R	I	I	S
L180M + M204V	R	R	I	I	S
A181A/T	I	S	S	R	S
N236T	S	S	S	R	I
L180M + M204V/I ± I196T ± V173L ± M250V	R	R	R	S	S
L180M + M204V/I ± T184G ± S202I/G	R	R	R	S	S

The amino-acid substitution profiles are shown in the left column and the level or susceptibility is given for each drugs: S (sensitive), I (intermediate/reduced susceptibility), R (resistant). EASL Clinical Practice Guidelines 2012.

Citation: Caligiuri P, Cerruti R, Icardi G, Bruzzone B. Overview of hepatitis B virus mutations and their implications in the management of infection. World J Gastroenterol 2016; 22(1): 145-154
URL: https://www.wjgnet.com/1007-9327/full/v22/i1/145.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i1.145