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Copyright ©The Author(s) 2015.
World J Gastroenterol. Oct 7, 2015; 21(37): 10584-10597
Published online Oct 7, 2015. doi: 10.3748/wjg.v21.i37.10584
Table 2 Genes suppressed in hepatocellular carcinoma; putative tumor suppressors
Symbol (location)Biological functionExpressionnRelevant clinical factorsFunctional analysesInteracting moleculesIn vivoRef.
ARNT2 (15q24)Partner for several sensor proteins of the bHLH-PAS familyIHC195OS, RFS, age, size, number, vascular invasion, AFP, differentiation, stageProliferation, invasion, migration-Yes79
BTG1 (12q22)Regulates cell growth and differentiationmRNA, IHC151OS, RFS, PIVKA-II, size, differentiation, vascular invasion, stage, extra-hepatic recurrence---80
CDH3 (16q22.1)Calcium-dependent cell-cell adhesion glycoproteinIHC69StageProliferation--71
EBP1 (12q13.2)RNA-binding protein involved in cell growth regulationIHC, WB103OS, grade, sizeGrowth, cell cycle--74
FBLN5 (14q32.1)Secreted extracellular matrix proteinmRNA, IHC86OS, number, vascular invasion, grade, stageMigration, invasionMMP7-76
Fbxw7 (4q31.3)Ubiquitin-mediated degradation of cyclin EIHC60OS, size, vascular invasion, grade, stageGrowth, apoptosisYAPYes77
GPx3 (5q23)Detoxification of hydrogen peroxidemRNA, IHC, ELISA113OS, RFS, size, number, vascular invasion, stageProliferation, invasionErk, NFκB, SIP1Yes75
IGFBP-1 (7p12.3)Mediator of the IGFsIHC90OS, differentiation, cirrhosis, vascular invasion, stageInvasionMMP9-73
LGALS4 (19q13.2)Modulating cell-cell and cell-matrix interactionsmRNA, IHC, ELISA201Size, differentiation, vascular invasion, stageMigration, invasion--72
TIPE1 (19p13.3)UnknownIHC50OS, gradeGrowth, apoptosisNec-1, Rac-1Yes78