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Copyright ©The Author(s) 2015.
World J Gastroenterol. Sep 28, 2015; 21(36): 10299-10313
Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10299
Table 2 Properties and functions of major apolipoproteins
NameMolecular weight (Da)OriginLipoprotein associationPrincipal function
apo A-I28016HepatocyteHDL>>CMCofactor of LCAT
Intestinal epithelial cellProstacyclin stabilizer
Ligand of SR-B1
apo A-II17414HepatocyteHDLInhibits LCAT
Intestinal epithelial cellInhibits HL
apo A-IV31570Intestinal epithelial cellCM(Activates LCAT?)
(hepatocyte?)(Activates CETP?)
apo B-48241000Intestinal epithelial cell (splicing variant of apo B-100)CM and CM remnantFormation of CM particle
apo B-100545000HepatocyteVLDL, IDL, and LDLFormation of VLDL/LDL particle
Ligand of LDL receptor
apo C-I6600HepatocyteCM, VLDL, IDL, and HDLInhibits CETP by altering the electric charge of HDL
apo C-II8800HepatocyteCM, VLDL, IDL, and HDLCofactor of LPL
apo C-III8750HepatocyteCM, VLDL, IDL, and HDLInhibits LPL and HL
Promotes assembly and secretion of VLDL
apo C-IVHepatocyteCM, VLDL, IDL, and HDLNot specified
apo E34100HepatocyteCM, CM remnant, VLDL, IDL and HDLLigand of LDL receptor/LDL receptor-related protein
MacrophageBinds to HSPGs