miR-122 negatively correlates with liver fibrosis as detected by histology and FibroScan

Figure 3 Correlation of miRNA expression with fibrosis stage, liver stiffness (measured by transient elastography), and alanine aminotransferase levels. A: The negative correlation of miR-122 (r = -0.4; P < 0.01) and miR-221 (r = -0.3; P < 0.03) with fibrosis stage; B: The negative correlation of miR-122 (r = -0.4; P < 0.01) and positive correlation of miR-224 (r = 0.3; P < 0.04) with liver stiffness; C: The positive correlation of miR-21 (r = 0.3; P < 0.04) with serum alanine aminotransferase (ALT) levels. The upper dotted lines indicate twofold elevation in expression; the lower dotted lines signify a one-half reduction of expression.