NOD2/CARD15 gene mutations in North Algerian patients with inflammatory bowel disease

Table 1 Demographic, clinical data and genotype-phenotype correlations in Crohn's disease patients n (%)

Variables	All subjects	Non carriers	Carriers	P value
HC	114	102 (89.47)	12 (10.52)	0.120
CD patients	86	70 (81.39)	16 (18.6)	0.103
Sex (F/M)	46/40	40/30	6/10	0.155
Age at diagnosis	25.28± 14.85	25.70 ± 15.55	22.12 ± 10.66
A1	28 (32.5)	22	6	0.809
A2	43 (50)	35	8
A3	15 (17.5)	13	2
Location
L1: Ileum	25 (29)	23	2	0.020
L2: Ileo-colon	49 (57)	35	14
L3: Colon	12 (14)	12	0
Resective Surgery	37 (43)	31	6	0.620
EIM	24 (28)	18	6	0.343
Positive family history for CD	23 (27)	17	6	0.281

A1 < 16, A2 = 16-40, A3 > 40 years according Montreal classification. CD: Crohn's disease; HC: Healthy controls; EIM: Extra intestinal manifestations.