Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients

Table 6 Univariate and multivariate analyses of factors associated with poor overall survival in patients with hepatitis C virus infection

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Age	1.025	0.987-1.065	0.195
Sex, male	1.328	0.668-2.642	0.418
Preoperative laboratory values
Aspartate transaminase	1.006	0.999-1.013	0.106
Alanine transaminase	1.001	0.992-1.009	0.849
Platelets	1.036	0.995-1.077	0.084
Serum ALB	0.246	0.114-0.531	< 0.0011	0.611	0.219-1.706	0.347
PT	0.994	0.971-1.018	0.643
Serum TBIL	1.206	0.523-2.780	0.660
ICGR15	1.054	1.021-1.087	0.0011	1.042	1.001-1.084	0.0471
Tumor markers
HH group	4.562	2.031-10.248	< 0.0011	4.018	1.424-11.337	0.0091
HL group	2.049	0.911-4.609	0.083	2.209	0.829-5.885	0.113
Intraoperative data
Blood loss	1.001	1.000-1.001	< 0.0011	1.000	0.999-1.001	0.727
Surgical duration	1.003	1.002-1.004	< 0.0011	1.002	0.998-1.005	0.414
Pathologic results
Tumor size	1.285	1.162-1.421	< 0.0011	1.081	0.946-1.235	0.255
Multiple tumors	1.204	1.021-1.420	0.0271	1.257	1.025-1.542	0.0281
Vascular invasion	2.223	1.221-4.045	0.0091	1.089	0.490-2.421	0.835

¹Represents statistical significance. HH group: Alpha-fetoprotein values > 21.0 ng/mL and des-gamma-carboxy prothrombin values > 67 mAU/mL; HL group: Alpha-fetoprotein values > 21.0 ng/mL or des-gamma-carboxy prothrombin values > 67 mAU/mL. ALB: Albumin; PT: Prothrombin; TBIL: Total bilirubin; ICGR15: Indocyanine green retention rate at 15 min.