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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 28, 2014; 20(48): 18070-18091
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18070
Table 3 Studies and their findings on ghrelin
HumanAG and the AG/DAG ratios positively associated with HOMA-IR in obese children[128]
IR obese subjects had elevated AG/DAG ratio compared with non IR obese subjects because of decreased DAG and total ghrelin levels[129]
Obese patients with MS had lower total ghrelin and DAG, comparable AG and higher AG/DAG, AG/DAG ratio correlated with IR[130]
Ghrelin significantly correlated with HOMA-IR, but was reduced in NAFLD[131]
Ghrelin levels were higher in higher stages of fibrosis in morbidly obese patients with NAFLD[132]
Higher total ghrelin concentrations in patients with NASH in comparison with steatosis and normal liver[54]
In vitroAdipocytes after incubation with AG and DAG significantly increased PPARγ and SREBP-1 mRNA levels and accumulated lipids[133]
Ghrelin inhibited AMP-activated protein kinase activity, through which also influenced PPAR-γ in liver and in adipose tissue[134]
Administration of ghrelin attenuated NAFLD-induced liver injury, oxidative stress, inflammation, and apoptosis partly through the action of serine/threonine kinase/AMPK and phosphoinositide 3-kinase/protein kinase B pathways in rats[135]