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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 14, 2014; 20(42): 15650-15656
Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15650
Table 1 Summary of completed and ongoing clinical human trials using exogenous bovine intestinal alkaline phosphatase
Area of studyStudy designRoute of administrationStudy phaseTreatment effectSample size/ Estimated enrollment1Ref.1
Completed trials
Coronary artery bypassRandomized, placeboIntravenous2Increased endogenous alkaline phosphatase release32Kats et al[47] (2012)
Severe sepsis and septic shock on acute kidney injuryDouble-blind, randomized and placeboIntravenous2Improved renal function36Heemskerk et al[49] (2009)
Moderate to severe ulcerative colitisUncontrolledOral2Short term improvement of moderate/severe ulcerative colitis20Lukas et al[50] (2010)
Sepsis in patients with acute kidney injury (AKI)Double-blind, randomized and placeboIntravenous2Renal protection from sepsis in patients with AKI36Pickers et al[48] (2012)
Ongoing trials
Acute rheumatoid arthritisNon-randomizedSubcutaneous1 and 2Ongoing study10NCT014164932
Safety and efficacy during heart surgeryRandomized double-blind, placebo-controlledIntravenous3Ongoing study228NCT011446112