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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jul 28, 2014; 20(28): 9384-9391
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9384
Table 2 A summary of published clinical trials testing curcumin in patients with pancreatic cancer
Dhillon et al[47]Kanai et al[48]Epelbaum et al[49]Kanai et al[69]
Sample size25211714
Study designPhase IIPhase I/IIPhase IIPhase I
Study period200812008-20092004-20062011-2012
Dose of curcumin8 g/d8 g/d8 g/d200 mg/d2 (n = 9) 400 mg/d2 (n = 5)
Prior history of chemotherapyYes (n = 22)Yes (n = 21)Noneyes (n = 14)
Concomitant use of anticancer drugNoYesYesYes
Major toxicity associated with curcuminNoneNoneAbdominal discomfort (n = 5)Abdominal pain (n = 2)
Median survival time (mo)NA5.454.4