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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jul 28, 2014; 20(28): 9384-9391
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9384
Table 1 A summary of representative preclinical studies on the anticancer effects of curcumin against pancreatic cancer
Reported molecular targetsCurcumin dose required for the reported effects
in vitro(μmol/L)in vivo
NF-κB↓ (Ref. 14)≥ 5.4NA
NF-κB↓, cyclin-D1↓≥ 251 g/kg per day, po
c-myc↓, Bcl-2↓
Bcl-xL↓, cIAP-1↓
VEGF↓ (Ref. 36)
NF-κB↓, Sp-1, Sp-3, Sp4↓≥ 25100 mg/kg per day, intraperitoneal injection
cyclin-D1↓, survivin↓
VEGF↓ (Ref. 27)
NF-κB↓, PGE2↓≥ 4NA
VEGF↓, miR-21↓
miR-200↑ (Ref. 28)