Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 28, 2013; 19(48): 9256-9270
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9256
Table 2 Curcumin’s anti-inflammatory and anticancer effects
Anti-inflammatory effectsAnticancer effects
Downregulation of NF-κB,Inhibition of carcinogen activation
Inhibition, via NF-κB, of COX-2, lipoxygenase, and iNOS enzymesStimulation of carcinogen detoxification
Inhibition of the inflammatory cytokines, such as TNF-α, interleukin (IL)-1, -2, -6, -8, and -12, MCP, and migration inhibitory proteinSuppression of pro-inflammatory signaling
Inhibition of PPAR-gInhibition of STAT
Induction of cancer cell apoptosis cell cycle arrest
Inhibition of angiogenesis and metastasis
Modulation of oncogenes and tumor suppressor genes