Hepatitis C virus protease inhibitor-resistance mutations: Our experience and review

Figure 1 Mutations in hepatitis C virus NS3/4A serine protease that impact susceptibility to hepatitis C virus drugs approved by the United States Food and Drug Administration and investigated in phase 2 or 3 clinical trials. The numbers indicate the positions of the amino acids of the hepatitis C virus genotype 1 Con 1 strain. The amino acids above and below the numbers indicate wild-type amino acids and their substitutions, respectively. The red color indicates the mutations detected among the population using sequencing in the present study.