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Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 14, 2013; 19(42): 7302-7307
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7302
Table 1 Pathophysiological and lifestyle related effects on drug absorption
PathophysiologyEffect on drug absorption
Low intraluminal pHThe drugs ability to cross the luminal wall
Motility disorderDelayed drug effect
Bacterial overgrowthDecreased absorption due to diarrhea or structural abnormalities
Pancreatic secretionLack of enzymes leads to inactivation of pro-drugs
SteatorrheaProblems with absorption of lipophilic drugs
Low body mass indexIncreased plasma concentration