Original Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Aug 14, 2013; 19(30): 4887-4896
Published online Aug 14, 2013. doi: 10.3748/wjg.v19.i30.4887
Figure 1
Figure 1 Features of irregular regeneration of hepatocytes. Microscopic views are shown of the biopsied liver tissues (F1 and F3 stage) of representative patients with hepatitis C virus infection. A: Dysplastic change; anisocytosis characterized by variability of cell size with focal dysplastic change [hematoxylin and eosin (HE); × 200]; B: Map-like distribution; distinct populations of hepatocytes with a homogeneous appearance within each population are separated from each other by a sharp outline (arrows) (HE; × 100); C: Bulging; expansive proliferation of hepatocytes compressing the surrounding parenchyma (HE; × 100); D: Oncocytes; oncocytic change of hepatocytes (HE; × 400); E: Nodularlity; nodular arrangement of the parenchyma (arrows) (HE; × 40); F: Atypical hepatocytes; degeneration of hepatocytes (arrows) (HE; × 400). These histopathological findings were scored using 5 grades: score 0, none; score 1, minimal (observed in less than one-third of the field); score 2, mild (observed in one-third to less than two-thirds of the field); score 3, moderate (observed in two-thirds or more of the field) and score 4, severe (diffusely in all fields). The findings were scored as the average (mean ± SD).