Original Article
Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 21, 2012; 18(43): 6226-6234
Published online Nov 21, 2012. doi: 10.3748/wjg.v18.i43.6226
Table 1 Optimized parameter values for the BxPC-3 and Capan-1 model
Model parameterValue
BxPC-3Capan-1
Global parameter
κ0 = EGFR phosphorylation (min-1)0.2930.438
κ1 = pEGFR attenuation (min-1)0.0670.155
κ2 = EGF-dependent ERK phosphorylation (a.u.-.1min-1)0.3880.482
κ3 = basal pERK dephosphorylation (min-1)3.688a
κ4 = EGF-dependent AKT phosphorylation (a.u.-1min-1)0.2250.044
κ5 = basal pAKT dephosphorylation (min-1)0.149a
κ6 = basal ERK phosphorylation (min-1)0.0670.104
κ7 = basal AKT phosphorylation (min-1)0.0130.007
κ8 = EGF-dependent pERK dephosphorylation (a.u.-1min-1)4.5128.520
κ9 = EGF-dependent pAKT dephosphorylation (a.u.-1min-1)2.9141.771
κ10 = pEGFR inhibition by erlotinib (μmol/L-1)39.06662.143
tau1 = delay for pERK (min)29.76666.809
tau2 = delay for pAKT (min)3.10913.803
Scaling parameter
erlotinib = 0 μmol/L
scale_pEGFR0.8580.540
scale_pERK61.33933.035
scale_pAKT13.48312.039
erlotinib = 0.11 μmol/L
scale_pEGFR1.5941.191
scale_pERK27.22429.561
scale_pAKT8.2318.254
erlotinib = 0.33 μmol/L
scale_pEGFR2.5221.955
scale_pERK35.32629.479
scale_pAKT5.5285.237
erlotinib = 1.0 μmol/L
scale_pEGFR6.2429.296
scale_pERK15.63115.464
scale_pAKT2.5692.340
Fixed parameter and initial condition
pEGFR (a.u.)00
EGFRtot = total EGFR (a.u.)11
AKTtot = total AKT protein (a.u.)11
ERKtot = total ERK protein (a.u.)11