Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 14, 2012; 18(42): 6036-6059
Published online Nov 14, 2012. doi: 10.3748/wjg.v18.i42.6036
Table 7 Factors that support the diagnosis of celiac disease in patients with an increased density of intraepithelial lymphocytes but no villous shortening[194] (printed with permission)
Family history of celiac disease15% of first-degree relatives are affected
Concomitant autoimmune conditionsRisk of coeliac disease approximately 5-fold
Increased density of γδ+ IELsSensitivity 0.84, specificity 0.91
Increased density of villous tip IELsSensitivity 0.84, specificity 0.95
HLA DQ2 or DQ8High sensitivity, low specificity
Negative predictive value high
Gluten dependenceShould be ascertained by gluten challenge or gluten-free diet