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Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Aug 7, 2012; 18(29): 3782-3786
Published online Aug 7, 2012. doi: 10.3748/wjg.v18.i29.3782
Figure 1
Figure 1 Proposed mechanisms explaining iron induced liver damage associated with steatosis and hepatic iron overload in hepatocytes (brown), macrophages (grey), and hepatic stellate cells (yellow). Cp: Ceruloplasmin; Fe-Tf: Ferric-transferrin; Fp-1: Ferroportin-1; HCC: Hepatocellular carcinoma; HFE: Hemochromatosis gene; HSCs: Hepatic stellate cells; MDA: Malonyl-dialdehyde; ROS: Reactive oxygen species; SOD2: Mn superoxide dismutase; Tf-R: Transferrin receptor. Modified from Dongiovanni et al[19].