Etiology of inflammatory bowel disease: A unified hypothesis

Figure 2 The dramatic increase in saccharin consumption since 1950s and the remarkable increase in inflammatory bowel disease during 1950s and 1970s in countries like the United States. A: Occurrence of ulcerative colitis (UC), Crohn’s disease (CD), and inflammatory bowel disease [inflammatory bowel disease (IBD) = UC + CD] in Monroe County, New York during 1920s to 1980s; B: A comparison of the temporal change of IBD in Monroe County, New York and the saccharin consumption in the United States; C: Correlation between IBD in Monroe County, New York and the saccharin consumption in the United States.