Decreased accumulation of ultrasound contrast in the liver of nonalcoholic steatohepatitis rat model

Figure 4 Changes in the signal intensity between control and methionine choline-deficient diet livers. A: Levovist^TM contrast enhanced ultrasonography (CEUS). In the methionine choline-deficient diet (MCDD) liver, there was a significant decrease in Levovist^TM signal intensity, compared to control livers at 2, 8 and 12 wk. While there was a lower tendency in signal intensity in MCDD liver than control liver at 4 and 16 wk, however, significance was not obtained; B: Sonazoid^TM CEUS. In the MCCD liver, there was a significant decrease in Sonazoid^TM signal intensity, compared to control livers at all time points. MCD: Methionine choline-deficient. ^aP < 0.05 vs control.