Copyright ©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 7, 2011; 17(37): 4166-4173
Published online Oct 7, 2011. doi: 10.3748/wjg.v17.i37.4166
Table 1 Summary of strategies to optimize thiopurine metabolite levels
MethodEffectiveness (%)Side effect
AZA to 6-MP48-73[45-48]Nausea, vomiting, hepatotoxicity, neutropenia, pancreatitis
6-MP to AZANot effective[48,50,51]Nausea, vomiting, hepatotoxicity, neutropenia, pancreatitis
Desensitization25[51]Hypersensitivity reaction
Combination infliximab/thiopurine25[72,74]Lymphoma, infection
6-TG46-82[50,58]NRH, veno-occlusive disease and possible tumor
Allopurinol supplementation25-75[68,69]Skin rash, renal impairment, leukopenia
Split-dosing60[75]Reduces 6-MP, AZA associated adverse effects