Clinicopathological significance of altered Notch signaling in extrahepatic cholangiocarcinoma and gallbladder carcinoma

Table 3 Correlation between cytoplasmonuclear coexistent localization of Notch receptors 1-4 and delta-like ligand-4 expression, and clinicopathological parameters

	Notch1			Notch 2			Notch 3			Notch 4			DLL4
Nuclear localization	-	+	P value	-	+	P value	-	+	P value	-	+	P value	-	+	P value
Total	78	18		57	40		65	32		4	99		36	48
Differentiation			0.545			0.418			0.556			0.036			0.175
Well	37	11		29	18		32	17		2	47		17	20
Moderate	34	6		22	20		27	14		0	43		14	26
Poorly	7	1		6	2		6	1		2	9		5	2
T stage			0.846			0.594			0.269			0.365			0.053
T1	12	4		11	5		8	9		0	16		5	9
T2	43	8		25	23		33	13		1	51		15	26
T3	18	5		18	10		20	8		3	26		11	13
T4	5	1		3	2		4	2		0	6		5	0
N stage			0.100			0.408			0.027			0.34			0.558
N0	52	16		44	27		41	28		2	70		27	32
N1	26	2		13	13		24	4		2	29		9	16

P by χ² test. DLL4: Delta-like ligand-4.