Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma

Table 4 Programmed death 1/programmed death ligands expression in liver tissues of patients with hepatitis (mean ± SD)

	n	PD-1	P	PD-L1	P	PD-L2	P
Age (yr)
< 36.6	12	1.67 ± 1.826	0.297	1.08 ± 1.240	0.873	1.83 ± 1.467	0.905
≥ 36.6	8	1.00 ± 0.926		1.00 ± 0.926		1.75 ± 1.581
Gender
Male	14	1.43 ± 1.604	0.903	1.07 ± 1.207	0.898	1.71 ± 1.437	0.702
Female	6	1.33 ± 1.506		1.00 ± 0.894		2.00 ± 1.673
ALT level (U/L)
Normal ( ≤ 40)	11	1.45 ± 1.440	0.866	1.27 ± 1.191	0.33	2.00 ± 1.673	0.517
Abnormal (> 40)	9	1.33 ± 1.732		0.78 ± 0.972		1.56 ± 1.236
TB level (μmol/L)
Normal ( ≤ 19)	13	1.46 ± 1.613	0.814	0.92 ± 0.862	0.496	1.77 ± 1.691	0.903
Abnormal (> 19)	7	1.29 ± 1.496		1.29 ± 1.496		1.86 ± 1.069
HAI score
< 4	12	1.00 ± 1.477	0.159	0.67 ± 0.778	0.053	1.50 ± 1.567	0.276
≥ 4	8	2.00 ± 1.512		1.62 ± 1.302		2.25 ± 1.282
Etiology
HBV	12	1.83 ± 1.528	0.125	1.42 ± 1.165	0.047	2.08 ± 1.311	0.304
Unknown	8	0.75 ± 1.389		0.50 ± 0.756		1.38 ± 1.685

PD: Programmed death; PD-L: Programmed death ligand; HBV: Hepatitis B virus; ALT: Alanine aminotransferase; TB: Total bilirubin; HAI: Histological activity index.