NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn’s disease

Table 1 IRGM, ATG16L1, and NOD2 genotypes of Crohn’s disease patients from whom monocytes were collected for ex vivo experiments

	IRGM		ATG16L1	NOD2				Clinical characteristics
Patient	rs133611891	rs49588471	T300A 1138G > Ars2241880	R702W 2104C > Trs2066844	P268S 802C > Trs2066842	G908R 2722G > Crs2066845	1007fs 3020insCrs2066847	Gender	Time since diagnosis (yr)	Disease location	Harvey bradshaw index2
1	TT	GG	AA	CC	CC	GG	00	M	53	Ileal	0
2	TT	GG	AA	CC	CC	GG	00	M	5	Ileo-colonic	0
3	TT	GG	AA	CC	CC	GG	00	F	5	Colonic	0
4	TT	GG	GG	CC	CC	GG	00	M	25	Ileo-colonic	2
5	TT	GG	AA	CC	CC	GG	00	F	6	Ileo-colonic	1
6	TT	GG	AA	CC	CC	GG	00	F	9	Ileal	3
7	TT	GG	AA	CC	CC	GG	00	M	1	Ileal	0
8	TT	GG	GG	CC	CC	GG	00	M	6	Colonic	2
9	TT	GG	GG	CC	CC	GG	00	F	10	Colonic	5
10	TT	GG	GG	CC	CC	GG	00	M	24	Ileo-colonic	1
11	TT	GG	GG	CC	CC	GG	00	F	11	Colonic	0
12	TT	GG	GG	CC	CC	GG	00	F	7	Ileo-colonic	4
13	TT	GG	GG	CT	CT	GG	00	F	5	Colonic	4
14	TT	GG	GG	CT	CT	GG	00	F	9	Ileo-colonic	0
15	TT	GG	GG	CT	CT	GG	00	M	17	Ileal	0
16	TT	GG	GG	CT	CT	GG	00	F	18	Colonic	4
17	TT	GG	GG	CC	CT	GG	0C	M	7	Ileal	1
18	TT	GG	GG	CT	CT	GG	00	F	16	Ileo-colonic	4

¹SNPs located upstream (5’) to IRGM;

²Non-invasive clinical index used to assess disease activity in patients with Crohn's disease. A score of ≥ 7 indicates active disease.