Silybin and the liver: From basic research to clinical practice

Table 6 Anti-inflammatory/antifibrotic effects of silybin[79-99]

Doses	Cells	Targets
From 5 to 50 μmol/L	Hepatocytes	Inhibition of NF-κB-mediated signaling
Mean: 15 μmol/L	Endothelial cells	Suppression of IκBα phosphorylation
	Platelets	Inhibition of protein kinase kinase
	Cancer cells	Inhibition of c-jun N-terminal kinase
	Phagocytes	Inhibition of leukotriene formation
	Stellate cells	Inhibition of release of cytochrome c
	HepG2	Inhibition of ERK, MEK, and Raf phosphorylation; inhibition of release of caspase 9 and 3, IL-8, and of PDGF- and TGF-β-mediated signaling; decrease of MMP2; increase of TIMP2; inhibition of HCV replication