Original Article
Copyright ©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 28, 2011; 17(16): 2086-2095
Published online Apr 28, 2011. doi: 10.3748/wjg.v17.i16.2086
Figure 10
Figure 10 A proposed diagram for α-mangostin-induced apoptosis in COLO 205 cells. Upon α-mangostin treatment, extrinsic pathway was activated, procaspase-8 was cleaved to caspase-8 which then further activated the cleavage of Bid to t-Bid. The t-Bid then translocates to mitochondria resulting in the activation of mitochondrial apoptotic pathway.