Brief Article
Copyright ©2010 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 14, 2010; 16(46): 5852-5860
Published online Dec 14, 2010. doi: 10.3748/wjg.v16.i46.5852
Figure 2
Figure 2 Pharmacological identification, with iberiotoxin (200 nmol/L), of the portion of the elicited outward K+ currents, using a ramp protocol from -140 to +60 mV, corresponding to BKCa channel currents in lower esophageal sphincter circular (n = 8) smooth muscle cells. Last 300 ms of representative traces shown. Sodium nitroprusside (SNP) induced a significant increase in elicited outward potassium currents vs control current density. Iberiotoxin (IbTX) alone blocked a significant portion of the control outward potassium currents. SNP added in the presence of IbTX, produced no significant increase in the outward currents. aP < 0.05.