Editorial
Copyright ©2010 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 7, 2010; 16(45): 5651-5661
Published online Dec 7, 2010. doi: 10.3748/wjg.v16.i45.5651
Table 1 Results of population-based studies showing liver toxicity induced by non-steroidal anti-inflammatory drugs
AuthorsStudy designIncidence rate of hepatotoxicity (ALT ≥ 3 ULN) per 100 000 patient-years (95% CI)
García Rodríguez et al[22], 1992Retrospective cohort study, cross over design9/100 000 (6-15)
Traversa et al[23], 2003Retrospective cohort1.4/100 000 (1.0-2.1)
de Abajo et al[24], 2004Retrospective population-based case-control study2.4/100 000 (2.0-2.8)
Rubenstein et al[26], 2004Systematic review (hospitalization or death)3.1 to 23.4/100 000
Rostom et al[21], 2005Systematic review0.29/100 000 (0.17-0.51)
Laine et al[25], 2009Long-term prospective trial2.1/100 000 (1.9-2.3)