A new index for non-invasive assessment of liver fibrosis

Table 5 Validation of liver fibrosis stages classification by liver fibrosis indices

	AUCs (95% CI)	Sensitivity (%)	Specificity (%)	Accuracy (%)	Positive predictive value (%)	Negative predictive value (%)	Positive likelihood ratio
F ≥ 1 (F0 vs F1-2-3-4)
Fibro-Stiffness index	0.80 (0.712-0.878)	73.6	78.6	74.2	94.0	27.7	3.52
Fibro-Stiffness index and AST	Non	78.3	78.6	78.3	96.5	32.4	3.64
Liver stiffness	0.82 (0.727-0.907)	63.2	85.7	65.8	97.1	23.5	4.42
APRI	0.80 (0.704-0.899)	87.7	35.7	81.7	91.2	27.8	1.36
Forns index	0.77 (0.659-0.880)	72.4	71.4	72.3	95.0	25.6	2.53
FibroIndex	0.83 (0.723-0.937)	89.6	50.5	85.8	93.1	38.9	1.79
F ≥ 2 (F0-1 vs F2-3-4)
Fibro-Stiffness index	0.82 (0.750-0.898)	65.7	96.6	76.7	90.6	63.8	10.31
Liver stiffness	0.85 (0.787-0.920)	76.7	83.0	79.2	87.5	69.6	4.51
APRI	0.82 (0.741-0.893)	50.7	89.4	65.8	88.1	53.8	4.76
Forns index	0.78 (0.700-0.864)	58.3	80.9	67.2	82.4	55.9	3.05
FibroIndex	0.79 (0.713-0.875)	69.5	83.0	74.2	86.2	62.9	4.02
F ≥ 3 (F0-2 vs F3-4)
Fibro-Stiffness index	0.93 (0.876-0.986)	93.9	83.9	86.7	68.9	97.3	5.84
Liver stiffness	0.92 (0.871-0.977)	81.8	82.8	82.5	64.3	92.3	4.75
APRI	0.83 (0.753-0.922)	75.8	81.6	80.0	61.0	89.9	4.12
Forns index	0.84 (0.759-0.912	78.1	71.3	73.1	50.0	90.0	2.72
FibroIndex	0.85 (0.772-0.928)	76.6	80.5	80.0	60.5	90.9	4.03
F = 4 (F0-1-2-3 vs F4)
Fibro-Stiffness index	0.97 (0.934-0.997)	100	84.1	85.8	43.3	100	6.29
Fibro-Stiffness index and HA	Non	100	86.9	88.3	48.1	100	7.63
Liver stiffness	0.97 (0.942-0.999)	100	83.2	85.0	41.9	100	5.94
APRI	0.92 (0.867-0.972)	100	75.7	78.3	33.3	100	4.12
Forns index	0.88 (0.798-0.968)	83.3	72.9	73.9	25.6	97.5	3.07
FibroIndex	0.92 (0.874-0.971)	100	77.6	80.0	35.0	100	4.46

AUCs: Area under the receiver operating characteristics; CI: Confidence interval; HA: Hyaluronic acid; AST: Aspartate aminotransferase; APRI: Aminotransferase-to-platelet ratio index.