A new index for non-invasive assessment of liver fibrosis

Table 2 Variables associated with fibrosis stage in the estimation group (165 patients ) in univariate analysis (mean ± SD)

	F0 (n = 14)	F1 (n = 52)	F2 (n = 42)	F3 (n = 33)	F4 (n = 24)	P-value
Liver stiffness (kPa)	5.58 ± 1.96	5.76 ± 1.91	9.02 ± 4.11	13.40 ± 4.95	20.77 ± 10.81	< 0.0001
Platelet count (× 104/mL)	20.80 ± 4.77	18.79 ± 5.19	15.66 ± 4.54	15.72 ± 5.58	11.75 ± 2.63	< 0.0001
Prothrombin time (%)	101.8 ± 10.3	96.1 ± 7.9	92.5 ± 7.9	88.7 ± 10.5	83.6 ± 9.6	< 0.0001
AST (IU/L)	30.3 ± 17.3	40.1 ± 23.7	46.9 ± 31.8	73.2 ± 40.3	77.0 ± 33.3	< 0.0001
ALT (IU/L)	44.4 ± 34.2	58.1 ± 47.1	62.5 ± 42.9	103.0 ± 72.9	94.6 ± 47.9	< 0.0001
Total protein (g/dL)	7.61 ± 0.30	7.78 ± 0.58	7.74 ± 0.44	7.83 ± 0.44	7.91 ± 0.48	0.4459
Albumin (g/dL)	4.52 ± 0.26 (n = 13)	4.44 ± 0.23 (n = 51)	4.32 ± 0.32	4.15 ± 0.24	4.12 ± 0.38	< 0.0001
γ-GTP (IU/L)	40.07 ± 26.10	57.52 ± 84.73	49.29 ± 32.91	75.79 ± 47.91	61.25 ± 40.46	0.2409
γ-globulin (g/dL)	1.22 ± 0.25 (n = 12)	1.44 ± 0.32 (n = 45)	1.52 ± 0.33 (n = 36)	1.62 ± 0.35 (n = 30)	1.83 ± 0.43 (n = 23)	< 0.0001
Total cholesterol (mg/dL)	179.5 ± 29.4	186.7 ± 31.5	173.8 ± 32.0	176.4 ± 26.8	162.3 ± 30.4	0.0251
Hyaluronic acid (ng/mL)	59.6 ± 83.1	49.64 ± 41.1 (n = 50)	110.3 ± 113.3	136.0 ± 138.4	266.6 ± 217.9 (n = 23)	< 0.0001

AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; γ-GTP: γ-glutamyl transpeptidase.