Influence of genes, sex, age and environment on the onset of autoimmune hepatitis

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Mar 7, 2009 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 7, 2009; 15(9): 1025-1034
Published online Mar 7, 2009. doi: 10.3748/wjg.15.1025

Table 2 Specific susceptibility genes in type 1 and type 2 autoimmune hepatitis

Genes	Population	Type of AIH	Linkage disequilibrium	References
MHC genes
HLA-A1-B8	North-America, Europe	1	Yes	[14 15]
HLA-DRB1*0301	North-America, UK, Spain, Argentina	1 and 2	Yes	[14 15 25]
HLA-DRB1*0401	North-America, Europe		ND	[14 15]
HLA-DRB1*0404	Mexico	1	ND	[18]
HLA-DRB1*0405	Argentina, Japan	1	-	[19 20]
HLA-DRB1*1301	North-America, Europe, Brazil, Argentina	1	Yes	[16 21]
HLA-DRB1-07	Germany, Brazil, UK	2	Yes	[23 24]
HLA-DRB3*01	Brazil			[22 23]
HLA-DQB1*0201	North-America, Europe	2	Yes	[16]
HLA-DQB1*0603	North-America, Europe	2	Yes	[16]
Non-MHC genes
IgA	Europe	1		[28 29]
C4A	Europe, North-America	1 and 2	Yes	[30 31]
CTLA4	North-America, Europe	1	Yes	[35 36]
Fas	Japan, North-America	1	ND	[37 38]
Vitamin D receptor	Germany	1 and 2	ND	[39]
TNFa*2	North-America, UK	1	Yes	[43 44]

ND: Non-determined.

Citation: Béland K, Lapierre P, Alvarez F. Influence of genes, sex, age and environment on the onset of autoimmune hepatitis. World J Gastroenterol 2009; 15(9): 1025-1034
URL: https://www.wjgnet.com/1007-9327/full/v15/i9/1025.htm
DOI: https://dx.doi.org/10.3748/wjg.15.1025