Original Articles
Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Sep 28, 2009; 15(36): 4518-4528
Published online Sep 28, 2009. doi: 10.3748/wjg.15.4518
Table 5 List of proteins with only a large BC and their functions
Protein nameFunction
HMGB1Binds to preferentially single-stranded DNA and unwinds double-stranded DNA
BTKPlays a crucial role in B-cell ontogeny
CSNK2A1Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates
CXCR4Transduces a signal by increasing the intracellular calcium ion level
CCL4Monokine with inflammatory and chemokinetic properties
RAC2Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytosis of apoptotic cells and epithelial cell polarization. Seems to be involved in the regulation of NADPH oxidase