Islet transplantation and antioxidant management: A comprehensive review

Table 2 In-vivo effects of antioxidants on pancreatic islets

Author	Substance/Dose	Sample	Procedure	Output
Thomas et al[23], 2007	Peptide SS-31 (3 mg/kg)	Mice → Mice	Injection of SS-31 to donor mouse + adding SS-31 during islet isolation	Better glucose control after transplant
Avila et al[29], 2005	L-glutamine (5 mmol/L)	Human → Rat	Transplantation of human islets which were treated before with/without intraductal L-glutamine to nude rats	Normoglycemia percentage ↑ (83% vs 26%) Time to reach normoglycemia ↓ (1.83 d vs 7.6 d)
Brown et al[40], 2005	Pyruvate Vitamin E Vitamin C	Rat → Rat	Oral administration of pyruvate, vitamin E and vitamin C during perioperative period	Pyruvate enhanced engraftment & functionality of suboptimal islet mass Vitamin E and vitamin C failed to enhance
Olcott et al[41], 2004	Salen-manganese [EUK-8] (100 mg/kg)	Mice → Mice	Daily treatment with/without EUK-8 (IP injection) to recipient NOD mice	Better glucose control until 20 d after transplant
Winter et al[42], 2002	Vitamin A (500 μg) Ascorbic Acid (40 mg) Vitamin E (10.6 mg) Selenium (2 μg)	Rat → Rat	Oral antioxidants, 24 h prior to transplantation	Slight better glucose control
Bottino et al[43], 2002	SOD mimetic compound (34 μmol/L)	Human → Mice	Culture of isolated islet in the presence of SOD mimetic for at least 2 h before transplantation	Better glucose control
Hardikar et al[35], 2001	Taurine (0.3 & 3 mmol/L)	Rat → Mice	Transplantation of islets which were previously cryopreserved with/without taurine	No significant difference was observed
Tajiri et al[37], 1999	Vitamin E (40 mg/kg)	Rat → Rat	Every other day IP injection of vitamin E to transplanted rats	Treatment for 2 not for 6 wk enhanced basal insulin release and arginine induced insulin release
Vajkoczy et al[44], 1997	Vitamin E (150, 8000 mg/kg)	Rat → Rat	Oral vitamin E after xenograft	Reduction of xenograft leukocyte- endothelium interaction at day 6 Adequate development of functional capillary density
Gembal et al[45], 1993	Allopurinol Vitamin E Chlorpromazine	Rat → Rat	Transplantation of islets which were pretreated with/without combination of allopurinol, alpha-tocopherol and chlorpromazine.	Better glucose control after 3 d

↑: Significant increase compared with non-treated group; ↓: Significant decrease compared with non-treated group.