Topic Highlight
Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jun 7, 2008; 14(21): 3350-3359
Published online Jun 7, 2008. doi: 10.3748/wjg.14.3350
Table 6 Evidence for the influence of immune mechanisms on the aetiology of PSC
Evidence for the influence of immune mechanisms
Humoral immunityIncreased circulating immune complexes
Elevated immunoglobulin levels (IgG and IgM)
Low titres of non-organ specific autoantibodies (ANA and SMA)
High titres of antineutrophil nuclear antibody (ANNA)
Cell mediated immunityDecreased levels of circulating peripheral CD8+ve Tcells
Portal T cell and NK cell infiltrate
Increased activated and memory T cells
Restricted T cell receptor repertoire (Vβ3)
Aberrant expression of HLA-DR on BEC
Coexpression of costimulatory molecules and HLA-DR on BECs
Abnormal expression of adhesion molecules on biliary epithelial cells
Abnormal expression of chemokine ligands on biliary epithelial cells
Immune effector mechanismsEnhanced cytokine expression in the liver
Immunogenetic mechanismsHLA associations