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Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jun 7, 2008; 14(21): 3350-3359
Published online Jun 7, 2008. doi: 10.3748/wjg.14.3350
Table 2 The features of primary sclerosing cholangitis compared with classical autoimmune disease
CharacteristicClassical autoimmune diseaseImmune-mediated inflammatory disease (such as IBD, psoriasis)Primary sclerosing cholangitis
AgeChildren and adultsChildren and adultsChildren and adults
SexFemale predominanceNo gender predilectionMale predominance
AutoantibodiesYes (pathogenic)Yes (markers)Yes (probably markers)
Associated autoimmune diseaseYesYesYes
HLA associations (class I and II)YesYesYes
Response to immunosuppressionUsually goodOften goodGood in children
Poor in adults