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©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jun 7, 2008; 14(21): 3350-3359
Published online Jun 7, 2008. doi: 10.3748/wjg.14.3350
Published online Jun 7, 2008. doi: 10.3748/wjg.14.3350
Table 2 The features of primary sclerosing cholangitis compared with classical autoimmune disease
| Characteristic | Classical autoimmune disease | Immune-mediated inflammatory disease (such as IBD, psoriasis) | Primary sclerosing cholangitis |
| Age | Children and adults | Children and adults | Children and adults |
| Sex | Female predominance | No gender predilection | Male predominance |
| Autoantigens | Yes | No | No |
| Autoantibodies | Yes (pathogenic) | Yes (markers) | Yes (probably markers) |
| Associated autoimmune disease | Yes | Yes | Yes |
| HLA associations (class I and II) | Yes | Yes | Yes |
| Response to immunosuppression | Usually good | Often good | Good in children |
| Poor in adults |
- Citation: Chapman R, Cullen S. Etiopathogenesis of primary sclerosing cholangitis. World J Gastroenterol 2008; 14(21): 3350-3359
- URL: https://www.wjgnet.com/1007-9327/full/v14/i21/3350.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.3350