Analysis of risk factors for the interval time, number and pattern of hepatic metastases from gastric cancer after radical gastrectomy

Table 3 Univariate and multivariate analysis of clinicopathologic factors potentially associated with the pattern of hepatic metastases after radical gastrectomy

		Cases of hepatic metastases after surgery
Factor	n	H1	H2	H3	Univariate P value	Multivariate P value	Odds ratio
Age
≤ 50 yr	13	2	7	4	0.221	0.098	2.034
51-69 yr	55	9	15	31	-	-	-
≥ 70 yr	19	1	9	9	-	-	-
Gender
Male	77	11	30	36	0.126	0.168	0.202
Female	10	1	1	8	-	-	-
Gastric carcinoma
Size
≤ 5 cm	39	10	13	16	0.014	0.618	0.758
> 5 cm	48	2	18	28	-	-	-
Location
Proximal	25	3	5	17	0.180	0.985	1.006
Middle	17	1	8	8	-	-	-
Distal	43	8	18	17	-	-	-
Diffuse	2	0	0	2	-	-	-
Histologic differentiation
Poorly undifferentiated	42	4	12	26	0.118	0.621	0.763
Well, moderately	45	8	19	18	-	-	-
Vascular invasion
Absent	70	12	28	30	0.011	0.190	4.267
Present	17	0	3	14	-	-	-
Neural invasion
Absent	74	12	28	34	0.087	0.844	1.235
Present	13	0	3	10	-	-	-
Depth of invasion1
T1	4	3	1	0	< 0.001	0.037	2.078
T2	26	6	13	7	-	-	-
T3	48	3	13	32	-	-	-
T4	9	0	4	5	-	-	-
Lymph node metastases1
N1	31	7	13	11	0.073	0.194	1.634
N2	37	5	13	19	-	-	-
N3	19	0	5	14	-	-	-
No. 12 lymph node group metastases
Absent	75	12	25	38	0.256	0.224	0.277
Present	12	0	6	6	-	-	-
No. 8 lymph node group metastases
Absent	72	11	26	35	0.603	0.677	1.483
Present	15	1	5	9	-	-	-
Lauren classification
Intestinal	36	10	17	9	0.001	0.005	2.552
Diffuse	29	0	8	21	-	-	-
Mixed	22	2	6	14	-	-	-
Surgical procedure
Esophago-proximal	23	3	8	12	0.807	0.698	1.122
Proximal subtotal	8	1	2	5	-	-	-
Distal subtotal	45	8	16	21	-	-	-
Total	11	0	5	6	-	-	-
Ascites
Absent	57	9	21	27	0.644	0.984	1.012
Present	30	3	10	17	-	-	-
Soft Tissue Invasion
Absent	47	6	22	19	0.057	0.765	1.179
Present	40	6	9	25	-	-	-

¹According to pTNM classification of UICC; Esophago-proximal, resection of the distal esophagus and proximal stomach; total, resection of the whole stomach.