Prolonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib (Iressa™) and to the antiangiogenic agent ZD6474: Cytotoxic and biomolecular effects

Figure 1 Drug-dependent cell growth inhibition. LoVo and HT-29 cells were incubated with gefitinib (0.12 and 1.2 µmol/L, respectively) or ZD6474 (0.6 and 5 µmol/L, respectively) for 7 and 14 d with continuous and intermittent exposure. Cell survival was determined by cell counts.