Colorectal Cancer
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Aug 28, 2006; 12(32): 5140-5147
Published online Aug 28, 2006. doi: 10.3748/wjg.v12.i32.5140
Table 3 Cell cycle and apoptosis modulation after prolonged exposure to gefitinib or ZD6474 in HT-29 and LoVo cells
LoVo cells
HT-29 cells
Drug exposureApoptosis(%)G0/G1(%)Apoptosis(%)G0/G1(%)
Control074.3 ± 1.3069.5 ± 1.4
Gefitinib1 wk continuous10.1 ± 0.580.4 ± 1.57 ± 0.470. 7 ± 1.7
2 wk continuous23.2 ± 0.987.9 ± 1.320 ± 1.277.2 ± 2.0
1 wk intermittent13.8 ± 0.675.4 ± 1.46.5 ± 0.367.1 ± 1.4
2 wk intermittent29.7 ± 0.878.0 ± 2.118.3 ± 1.869.7 ± 1.9
Control074.3 ± 2.1069.5 ± 1.8
ZD64741 wk continuous15.4 ± 0.677.6 ± 1.97 ± 0.971.7 ± 2.1
2 wk continuous30.3 ± 0.981.8 ± 2.315 ± 0.875.2 ± 2.4
1 wk intermittent18.3 ± 1.374.6 ± 2.17.3 ± 1.170.2 ± 1.8
2 wk intermittent29.6 ± 1.576.5 ± 1.516.4 ± 2.272.0 ± 1.7